The objective of this empirical study was to investigate the relationship between employee satisfaction and employee retention among nurses in the United Arab Emirates (U.A.E.), namely in Abu Dhabi's hospitals. A self - administered questionnaire was developed as the primary data collection method. Data was then analysed using SPSS Statistics 20.0 software. The questionnaire was distributed and delivered to 255 nurses in five hospitals in Abu Dhabi. Descriptive statistics as well as correlation and multiple regression analysis techniques were employed to establish the relationship between the variables. Variables such as employee rewards, role ambiguity, organizational support and organizational commitment were found to be significantly influential towards job satisfaction, while there was no significant association between employee rewards, organizational commitment and employee job satisfaction. The study revealed that independent variables correlation with dependent variable and the study indicated that the employee rewards and organizational commitment lead to employee satisfaction but however, they do not result in job satisfaction. Based on the findings, a number of recommendations were introduced to enhance and improve the factors that influenced job satisfaction and employee retention in Abu Dhabi's hospitals. Contributions to Human Resource Management (HRM) for future research were addressed and discussed. © Serials Publications Pvt. Ltd.