Abstract View references (31) When linked, Innovation, Entrepreneurship and Leadership provide a platform for Organizational survival. This paper develops a framework for innovation–a necessary condition that requires the appropriate leadership in order to guide its course in the right direction. Innovation Proficiency stems from two major elements: the interior and the exterior. The interior element includes three constituents: knowledge, attitude, and imagination. The exterior element also includes three constituents: culture, resources and habitat. While the exterior element is related to the outer world and one's environment, the interior one relates to us as people. The aim of this paper is to combine and investigate Seelig's model for the Innovation Engine and to evaluate the Kuratko entrepreneurship platform. The paper, which is based on both platforms, evaluates the innovation progression and entrepreneurship base within several industries in the Middle East and North Africa regions (referred to as the MENA region). A survey, which was distributed to leaders in several major industries, was collected, analyzed, and presented. © 2019, © 2019 African Journal of Science, Technology, Innovation and Development